Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.7
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%
Top Medical Research Studies
7
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
7
We aimed to understand the effects of magnesium sulfate treatment on a patient with chronic fatigue syndrome. The case involved a 29-year-old woman experiencing severe fatigue alongside various symptoms, including swelling lymph nodes and muscle pain.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
Most Useful Reviews
10
Life-changing effects
9 people found this helpful
This supplement has truly changed my life; I was overwhelmed by fatigue and struggled to work. The severe symptoms I experienced have thankfully disappeared. What I once thought required hormone treatments was actually resolved by this simple supplement. I can hardly believe the difference it has made.
9
Cumulative relief
This supplement has a cumulative effect and significantly relieves fatigue. I no longer experience night cramps in my legs.
8
Less fatigue
I am very satisfied with the results as I experience less fatigue than usual.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
- All Researches
9
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
8
Magnesium potentially benefits CFS patients
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.
In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
8
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
8
Beta-glucan improves cognitive fatigue
We conducted a study to explore the potential benefits of beta-glucan supplementation in individuals suffering from chronic fatigue syndrome (ME/CFS). Over 36 weeks, we engaged 65 patients in a randomized, double-blind trial where they received either a daily combination of beta-glucan, vitamin D3, vitamin B6, and zinc, or a placebo that contained only microcrystalline cellulose. This approach allowed us to assess the overall impact of this nutritional supplement on fatigue, sleep quality, anxiety, and cognitive performance.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing effects
9 people found this helpful
This supplement has truly changed my life; I was overwhelmed by fatigue and struggled to work. The severe symptoms I experienced have thankfully disappeared. What I once thought required hormone treatments was actually resolved by this simple supplement. I can hardly believe the difference it has made.
9
Cumulative relief
This supplement has a cumulative effect and significantly relieves fatigue. I no longer experience night cramps in my legs.
8
Less fatigue
I am very satisfied with the results as I experience less fatigue than usual.
7.5
Preventive against stress
I ordered this for my mum and a friend, and they were pleased; results were apparent within a week. I recommend this supplement for preventing fatigue and stress, and I may consider it for myself if my doctor prescribes magnesium.
Frequently Asked Questions
7.5
Preventive against stress
I ordered this for my mum and a friend, and they were pleased; results were apparent within a week. I recommend this supplement for preventing fatigue and stress, and I may consider it for myself if my doctor prescribes magnesium.
9
Cumulative relief
This supplement has a cumulative effect and significantly relieves fatigue. I no longer experience night cramps in my legs.
10
Life-changing effects
9 people found this helpful
This supplement has truly changed my life; I was overwhelmed by fatigue and struggled to work. The severe symptoms I experienced have thankfully disappeared. What I once thought required hormone treatments was actually resolved by this simple supplement. I can hardly believe the difference it has made.
4
We systematically reviewed randomized controlled trials on complementary and alternative medicine (CAM) treatments for chronic fatigue syndrome (CFS).
Although 26 studies involving over 3,000 participants explored various therapies, the findings showed limited effectiveness overall.
While some treatments like massage and specific dietary supplements had some positive effects, most failed to provide significant benefits.
Notably, magnesium showed potential, but due to small sample sizes and biases in the studies, we can't make firm conclusions just yet. More rigorous studies are needed to confirm these effects.
Although 26 studies involving over 3,000 participants explored various therapies, the findings showed limited effectiveness overall.
While some treatments like massage and specific dietary supplements had some positive effects, most failed to provide significant benefits.
Notably, magnesium showed potential, but due to small sample sizes and biases in the studies, we can't make firm conclusions just yet. More rigorous studies are needed to confirm these effects.
7
We aimed to understand the effects of magnesium sulfate treatment on a patient with chronic fatigue syndrome. The case involved a 29-year-old woman experiencing severe fatigue alongside various symptoms, including swelling lymph nodes and muscle pain.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
7
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
7
We investigated how magnesium levels relate to chronic fatigue by studying 93 patients with unexplained fatigue.
Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.
Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.
However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.
Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.
However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
References
- Alraek T, Lee MS, Choi TY, Cao H, Liu J. Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review. BMC Complement Altern Med. 2011;11:87. doi:10.1186/1472-6882-11-87
- Manuel y Keenoy B, Moorkens G, Vertommen J, Noe M, Nève J, et al. Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr. 2000;19:374.
- Takahashi H, Imai K, Katanuma A, Sugaya T, Hisano K, et al. [A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate]. Arerugi. 1992;41:1605.
- Uchida A. [Therapy of chronic fatigue syndrome]. Nihon Rinsho. 1992;50:2679.
- Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet. 1991;337:757.
- Ranisavljev M, Stajer V, Todorovic N, Ostojic J, Cvejic JH, et al. The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial. Eur J Nutr. 2024;64:28. doi:10.1007/s00394-024-03546-0
- Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, et al. Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17040463
- Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15214504
- Imai K, Yamano T, Nishi S, Nishi R, Nishi T, et al. Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment. Viruses. 2022;14. doi:10.3390/v14050907
- Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10071010
- Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29:902.
- Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.
